自成立以来，倍森生物及下属的倍森基因技术研究所 (Puensum Genetech Institute) 长期专注于微生物基因组学和宏基因组学领域的基础研究、临床应用与开发。基于不断完善的实验及数据分析平台，我们广泛地研究了人体各个部位 (肠道、口腔、皮肤及生殖道) 的微生物组特征，探索了个人微生物组与多种疾病、动物和环境之间的关系，积累了大量的技术与经验；并且在微生物培养组学、代谢组学、病毒组学等新方向上也有突破。
我们拥有高素质的科研团队和优秀管理人员，覆盖了生物信息学、计算机科学、临床医学和营养学等多个专业方向的精英；此外，还有国内外顶尖的微生物学家和资深医学专家作为科学顾问。科研方面，倍森生物目前已有 100 多篇高水平学术论文在 <Nature Communications>、<Gut>、<Am J Respir Crit>、<Clin Microbiol Infect> 等国际顶尖期刊上发表，总影响因子超过 600+。合作院所包括北京大学、北京中医药大学、大连医科大学、广州医科大学、中山大学附属肿瘤医院、华中科技大学附属同济医院等。
自身免疫性疾病
合作单位：北京大学人民医院、贵州中医药大学研究内容：通过对类风湿性关节炎、骨关节炎、系统性红斑狼疮等免疫性疾病的大规模研究，探索其肠道及口腔微生物组信号及致病机理，开发针对自身免疫病的微生物干预方案。
1. Ruochun Guo, ... (2022) Dysbiotic oral and gut viromes in untreated and treated rheumatoid arthritis patients. Microbiology Spectrum.
2. ..., Qiulong Yan, ... (2022) Characterizations of the gut bacteriome, mycobiome, and virome in patients with osteoarthritis. Microbiology Spectrum.
3. ..., Shenghui Li, ... (2022) Tonsillar microbiome-erived lantibiotics induce structural changes of IL-6 and IL-21 receptors and modulate host immunity. Advanced Science.
4. ..., Shenghui Li, ... (2019) Mining the human tonsillar microbiota as autoimmune modulator. bioRxiv.
消化系统疾病
合作单位：大连医科大学、中山大学附属肿瘤医院研究内容：通过对结直肠癌、炎症性肠病、肠易激综合征、胆囊炎等消化系统疾病的研究，挖掘肠道微生物的机理和诊断价值，分离特异性的致病菌和有益菌，为临床预防和治疗提供帮助。
1. Fang Chen, ... (2022) Meta-analysis of fecal viromes demonstrates high diagnostic potential of the gut viral signatures for colorectal cancer and adenoma risk assessment. Journal of Advanced Research.
2. ..., Shenghui Li, ... (2022) Cultivated human intestinal fungus Candida metapsilosis attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists. Gut.
3. Qiulong Yan, ... (2021) Cultivation and genomic characterization of the bile bacterial species from cholecystitis patients. Frontiers in Microbiology.
4. ..., Qiulong Yan, ... (2015) Acute cholecystitis associated with infection of Enterobacteriaceae from gut microbiota. Clinical Microbiology and Infection.
慢性和老年疾病
合作单位：中国农业大学、中国科学院生命科学研究所、广州医科大学研究内容：通过对高血压、冠心病、慢性肾病、糖尿病、阿兹海默症等疾病的肠道微生物组和代谢组研究，探索微生物对人体代谢系统和疾病的作用，为慢性和老年疾病的预防和干预提供指导。
1. ..., Shenghui Li, ... (2022) Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression. Molecular Psychiatry.
2. ..., Shenghui Li, ... (2021) Comparison of the gut microbiota of short-term and long-term medical workers and non-medical controls: a cross-sectional analysis. Clinical Microbiology and Infection.
3. ..., Shenghui Li, ... (2021) Characterization of the genitourinary microbiome of 1,165 middle-aged and elderly healthy individuals. Frontiers in Microbiology.
4. ..., Shenghui Li, ... (2020) Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut.
5. ..., Shenghui Li, ... (2020) An A. muciniphila subtype alleviates high-fat diet-induced metabolic disorders and inhibits the neurodegenerative process in mice. Anaerobe.
6. Qiulong Yan, ... (2017) Alterations of the gut microbiome in hypertension. Frontiers in Cellular and Infection Microbiology.
7. Zhuye Jie, ... (2017) The gut microbiome in atherosclerotic cardiovascular disease. Nature Communications.
母婴微生物组及妊娠期疾病
合作单位：广州医科大学、广东省儿童医院、北京中医药大学研究内容：大规模调查孕妇和儿童的肠道、口腔和生殖道微生物组特征，开发针对性的益生菌和微生物制剂，为改善女性和儿童的健康保驾护航。
1. ..., Wen Sun. (2022) Metagenomic-based characterization of the gut virome in patients with polycystic ovary syndrome. Frontiers in Cellular and Infection Microbiology.
2. ..., Shenghui Li, ... (2022) Deep metagenomic characterization of gut microbial community and function in preeclampsia. Frontiers in Cellular and Infection Microbiology.
3. ..., Shenghui Li, ... (2021) Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta. Protein & Cell.
4. ..., Ruochun Guo, ... (2021) Gut microbiota signatures in gestational anemia. Frontiers in Cellular and Infection Microbiology.
5. ..., Ruochun Guo, ... (2020) Systematic analysis of gut microbiota in pregnant women and its correlations with individual heterogeneity. npj Biofilms and Microbiomes.
6. ..., Shenghui Li, ... (2019) Early-onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women. Frontiers in Cellular and Infection Microbiology.
7. ..., Shenghui Li, ... (2017) Connections between human gut microbiome and gestational diabetes mellitus. GigaScience.
8. ..., Shenghui Li, ... (2016) Effect of short-term room temperature storage on the microbial community in infant fecal samples. Scientific Reports.
9. ..., Shenghui Li, ... (2016) Composition of gut microbiota in infants in China and global comparison. Scientific Reports.
动物和环境微生物
合作单位：华南农业大学、青岛农业大学研究内容：研究动物和环境的微生物组和耐药组特征，探索人类微生物与动物和环境的关系，为预防感染、减少抗生素使用提供新的思路；对动物疾病的检测和干预也提供帮助。
1. ..., Shenghui Li, ... (2022) A catalog of over 5,000 metagenome-assembled microbial genomes from the Caprinae gut microbiota. Microbiology Spectrum.
2. ..., Shenghui Li, ... (2020) Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms. Nature Communications.
3. ..., Shenghui Li, ... (2019) Characterization of the pig gut microbiome and antibiotic resistome in industrialized feedlots in China. mSystems.
4. ..., Qiulong Yan, ... (2018) Isolation of γ-glutamyl-transferase rich-bacteria from mouse gut by a near-infrared fluorescent probe with large stokes shift. Analytical Chemistry.
5. ..., Qiulong Yan, ... (2018) Diterpenoids from the roots of Euphorbia ebracteolata and their anti-tuberculosis effects. Bioorganic Chemistry.
微生物组新技术与新方法
合作单位：华中科技大学、南京中医药大学、内蒙古农业大学研究内容：探索微生物基因组学和宏基因组学领域新技术与新方法，目前的工作包括mNGS病原体检测技术、宏病毒组学技术、高深度测序、细菌群体遗传学研究等。
1. ..., Shenghui Li, ... (2022) Hybrid, ultra-deep metagenomic sequencing enables genomic and functional characterization of low-abundance species in the human gut microbiome. Gut Microbes.
2. Guangyang Wang, ... (2022) Optimization and evaluation of viral metagenomic amplification and sequencing procedures toward a genome-level resolution of the human fecal DNA virome. Journal of Advanced Research.
3. Shenghui Li, ... (2022) A catalogue of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome. iScience.
4. ..., Shenghui Li, ... (2022) A thousand metagenome-assembled genomes of Akkermansia reveal phylogroups and geographical and functional variations in the human gut. Frontiers in Cellular and Infection Microbiology.
5. Qiulong Yan, ... (2021) Characterization of the gut DNA and RNA viromes in a cohort of Chinese residents and visiting Pakistanis. Virus Evolution.
6. ..., Shenghui Li, ... (2017) Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas. BMC Genomics.
7. Qiulong Yan, ... (2016) Metagenomic analysis of sputum microbiome as a tool toward culture-independent pathogen detection of patients with ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine.